Main cast[]
- Cathy Cavadini and Grey Delisle, Amanda Leighton as Blossom Utonium
- Kath Soucie, Tara Strong and Kristen Li as Bubbles Utonium
- E.G. Daily, Tara Strong, Natalie Palamides as Buttercup Utonium
- Tom Kane as Professor Anthony Utonium, Him
- Tom Kenny as Mayor Of Townsville/Barney
- Jennifer Hale as Ms. Keane/Sandy
- Jennifer Martin as Ms. Bellum/Sara
- Roger L. Jackson as Mojo Jojo
- Jeff Bennett as Various characters
- Bruce Campbell as Johnny Rocco
- Adam Steven Evans as Bobby Derek
Guest voices[]
- Aaron Spann - Mike Believe
- Alex Borstein - Various Characters
- Allyce Beasley - Woman
- Amy Sedaris
- Andrea Martin
- Anais Fairweather
- Andrea Romano
- April Stewart
- April Winchell
- Ashley Tisdale
- Audrey Wasilewski
- Benjamin Diskin - Logan
- Betsy Sodaro - Eddie
- Bill Fagerbakke
- Billie Hayes - Old Lady
- Billy West
- Bob Bergen
- Bob Joles
- Brigitte Bako
- Cameron Esposito
- Candi Milo - Cleaner
- Carlos Alazaraqui
- Carolyn Lawrence
- Catherine Reitman - Robin Synder, Old Lady in Van
- Catherine Taber
- Charlie Adler
- Charlie Bean
- Chelsea Kane
- Cheryl Chase
- Christine Cavanaugh - Bunny
- Chuck McCann
- Cindy Robinson
- Clancy Brown
- Coleen O' Shaugnessey
- Corey Burton
- Courtenay Taylor
- Cree Summer - Green Wing/Edith
- Cristina Pucelli
- Daran Norris
- David Kaufman, Deanna Oliver
- Debi Derryberry
- Dee Bradley Baker
- Dee Dee Rescher
- Derin Basden
- Diane Delano
- Diane Michelle
- Dionne Quan
- Don Shank
- Dwight Schultz
- Eliza Jane Schnieder
- Erica Lutrell
- Eric Bauza
- Francesca Marie Smith
- Frank Welker
- Fred Tatasciore
- Gail Matthius
- Georgie Kidder
- Gillian Jacobs
- Greg Eagles
- Gregg Berger
- Greg Proops
- Grey Delisle
- Gwendoline Yeo
- Haley Mancini
- Hynden Walch, Jack Fletcher
- Jacquie Barnbrook
- James Arnold Taylor
- James Kirkland
- James Marsden
- James Patrick Stewart
- Janice Kawaye
- Janie Haddad
- Jason Kaye
- Jason Marsden
- Jason Spisak, Jean Smart
- Jeff Bergman
- Jess Harnell
- Jessica DiCicco
- Jill Talley
- Jim Cummings
- Jodi Carlisle
- John DiMaggio
- John O' Hurley
- Josh Fadem
- Josh Peck
- Joshua Black
- Julia Kato
- Julianne Grossman
- Julie Nathanson
- June Foray
- Karen Maruyama
- Karen Strassman
- Kari Wahlgren
- Kate Higgins
- Kate McKinnon
- Kate Micucci
- Katey Sagal
- Kat Cressida
- Kathyrn Fiore
- Kath Soucie
- Kathy Griffin
- Katy Mixon
- Keith Ferguson
- Kelsy Abbott
- Keone Young
- Kerri Kenney- Silver
- Kevin Michael Richardson
- Kimberly Brooks
- Kirby Howell Baptiste
- Kyle Carrozza, Kyla Rae Kowalewski
- Laraine Newman
- Lara Jill Miller
- Laura Bailey
- Laura Silverman
- Lauren Tom
- Lauri Fraser
- Leigh Allyn Baker
- Leslie Carrara
- Lily Vonnegut
- Lisa Ortiz
- Lori Alan
- Lou Romano
- Maggie Roswell
- Maile Flanagan
- Marcia Wallace
- Maria Bamford
- Marissa Jaret Winokur, Marieve Herington
- Mark Hamill
- Marley Shelton
- Masasa Moyo
- Maurice Lamarche
- Mayim Bialik
- Megan Cavanagh
- Melanie Chartoff
- Michael Bell
- Michael Patrick Bell, Mindy Sterling
- Missi Pyle
- Mo Collins, Mona Marshall
- Nancy Cartwright
- Nancy Linari
- Nicole Sullivan, Nicholas Cantu
- Nika Futterman
- Nolan North
- Nora Dunn
- Olivia Hack
- Paget Brewster
- Pamela Adlon
- Pamela Hayden
- Pat Pinney
- Paul Mercier, Paul Schoeffler
- Peri Gilpin
- Phil LaMarr
- Phyllis Diller
- Rachael Macfarlane
- Rachael Russakoff
- Richard Steven Horvitz
- Ringo Starr
- Robbie Rist
- Rodger Bumpass
- Roger Craig Smith
- Roger Rose
- Rosie O'Donnell
- Russi Taylor
- Sandra Bernhard
- Sandy Fox
- Sarah Chalke
- Sarah Silverman
- Scott Menville
- Sherri Stoner, Sirena Irwin
- Sonal Shah
- S. Scott Bullock
- Stephanie Nadolny
- Stephanie Sheh
- Steve Blum
- Sunil Maholtra
- Susanne Blakeslee
- Takayo Fischer
- Tania Gunadi
- Teresa Ganzel, Tisha Terrasini Banker
- Tony Pope
- Townsend Coleman
- Travis Willingham
- Tress Macneille
- Trevor Devall
- Troy Baker
- Vanessa Marshall
- Vernee Watson Johnson
- Veronica Taylor
- Vincent Tong, Wally Wingert
- Wendee Lee
- Wendy Schaal
- Yeardley Smith
- Yuri Lowenthal
Related Cast from Powerpuffsploitation trilogy ''Nutri Ventures'' and ''Kid Cosmic'', ''Dexter's Lab 2023''[]
- Cam Clarke, Jason Marsden, Charlie Schlatter, Jeff Fischer as Theo Angelo
- Mona Marshall, Sarah Silverman, Jessica DiCicco, Julia McIlvaine as Lena Giancarlo
- Grey DeLisle-Griffin, Sarah Chalke, Jessie Flower, Ashly Burch as Nina Giancarlo
- Daran Norris, Jim Cummings, Travis Willingham as Alex Grand
- Paget Brewster, Betsy Sodaro, Wendi McLendon-Covey as Teacher Phyllis
- Tom Kenny, Sam Riegel as Guardian Purple
- Marley Shelton, Pamela Adlon as Genevieve
- Laraine Newman, Diane Delano, Tress MacNeille, Marcia Wallace, Audrey Wasilewski, Cree Summer, Wendee Lee and Laurie Metcalf, Tasia Valenza, Ben Diskin, Nicole Sullivan, Amanda Leighton, Catherine Cavadini, Grey Delisle-Griffin, Marieve Herington, Natalie Palamides, Kristen Li, Cheri Oteri, Cheryl Hines, Hiromi Dames as various colored Gugas vocalizations
- Dee Bradley Baker as Nexus/Nate, Theo's dad/Mr. Angelo
- Mindy Sterling as Mrs. Grand, Theo's mom/Mrs. Angelo
- Fred Tatasciore, Chad Doreck, Jason Marsden, Josh Peck, Dave Boat, James Arnold Taylor as G-Squads
- Sandra Bernhard as Jomanda
- Jeff Garcia as Fritz Jr.
- Mark Moseley as Fritz
- Patti LuPone, Linda Hamilton, Jennifer Hale, Lauri Fraser as Dragon vocalizations
- Chad Doreck, Nick Palatas as Nose/Wynn
- Catherine Reitman, Rachel Dratch, Vanessa Marshall as Pecky, Dratch also voices Guardian White.
- Megan Hilty, Tara Strong, Tori Spelling as Sheriff Brown
- Nora Dunn, Jill Talley, Rachael MacFarlane as Betty Beans
- Jess Harnell as Sacred Eagle
- JP Karliak as Ragg/Randall Dylan
- Keone Young as Oracle
- Catherine Taber and Jacquie Barnbrook as Matron 1, Matron 2
- Pat Musick, Kari Wahlgren as Tucan
- Melissa Villaseñor as Boa
- Lauren Tom, Misty Lee as Mountain Golem
- Mayim Bialik as Inca, Tucan
- Sandy Fox as Captain Scarlet
- Phil LaMarr as Captain Mist, Additional voices
- Robbie Daymond as Guardian Blue
- Josh Fadem as Sid
- Maria Bamford as Tina
- Sam Riegel as Candyman, Crato Leader
- Valery Pappas as Villager 2, Additional voices
- Kathy Griffin as Cientist 4, Additional voices
- Andrea Romano as Additional voices
- Ian James Corlett as Mechanic
- Cree Summer as Student 2
- Sarah Thyre as Girl 3
- Mary Birdsong as Kid 2
- Alanna Ubach as Kid Walla
- June Angela and James Arnold Taylor as Whale God
- Kimberly Brooks as Kid 9
- Takayo Fischer as Additional voices
- Amy Hill as Citizen 4
- Maurice Lamarche as Additional voices
- Daisy Lawless as Additional voices
- Lauren Lapkus as Girl 6, Additional voices
- Masasa Moyo as Villager 10, Additional voices
- Debi Derryberry as Walla 1
- Jim Ward as Additional voices
- Frank Welker as Additional voices
- Lara Jill Miller as Kid 12
- Amber Hood as Additional voices
- Nat Faxon as Tyler
- Eddie Deezen as Mr. Hildebrand
- Nico Colaleo as Phil
- Jim Hanks as Professor Gizmo
- Caroline Rhea as Guardian Orange
- Susan Silo as Additional voices
- Paula Tiso as Additional voices
- Jack Angel as Additional voices
- Will Friedle as Additional voices
Additional Voices:
- Candi Milo
- Mila Kunis
- Melanie Chartoff
- Edie Mirman
- John Kassir
- Richard Steven Horvitz
- Kevin Michael Richardson
- Yvette Nicole Brown
- Katie Leigh
- Jentle Phoenix
- Sirena Irwin
- Linda Wallem
- Josh Keaton
- Nicole Byer as Narrator/Announcer
- Tasia Valenza as Ben (Season 1), Additional voices
- Olivia Olson as Ben (Season 2)
- Busy Philipps as Ben (Season 3 and 5)
- Brianne Siddall as Ben (Season 4)
- Susie Essman
- Jeff Fischer
- Dwight Schultz
- Robin Atkin Downes
- Susanne Blakeslee
- Haley Tju
- Phil LaMarr and Greg Cipes
Kid Cosmic Cast[]
- Jack Fisher as Kid Cosmic/Kid/King Man 2
- Amanda Céline Miller as Jo
- Lily Rose Silver as Rosa
- Keith Ferguson as Papa G
- Kim Yarbrough as Flo
- Christina Lanz as Carlos
- Fred Tatasciore as Tuna Sandwich
- Jason Hightower as Biker in Black/Jace
- Tom Kenny as Chuck
- Sam Riegel as PTSB/Pretender Terror Super-Bot
- Eric Bauza as Fry
- Michaela Dietz as Blue Behemoth
- Phil LaMarr as Golden Swarm
- Rich Fulcher as Saucerman
- Cree Summer as Queen Xhan
- Bobby Moynihan as Fantos
- April Winchell as Krosh
- Toks Olangundoye as Madame President
- Cathy Cavadini as Agent Pink/Fake Blossom
- Tara Strong as Agent Blue/Fake Bubbles
- E.G. Daily as Agent Green/Fake Buttercup
- Cheri Oteri as Mo (deleted scenes, flashback)
- Laura Bailey as Kid's mom (final result)
- Travis Willingham as Kid's dad (final result)
- Jack McBrayer as Skippy Olsen
- Piotr Michael as Doc Goomentarian
- Jennifer Hale as Iris
- Jill Talley as Additional voices
- Kari Wahlgren as Inspector
- Ike Amadi as Agency Boss
- Andy Bean as Creature vocalizations
Dexter's Lab HBO Max reboot 2023 Voice Cast[]
- Haley Tju as Dexter
- Bella Thorne as Dee-Dee
- Travis Willingham as Dexter's Dad/Danny
- Amanda Leighton as Dexter's Mom/Deborah
- Ashleigh Crystal Hairston as Mee-Mee
- Kristen Li as Lee-Lee
- Anna Akana as Andrea/Ghost Woman.
- Rob Paulsen as Major Glory, Uncle Drake
- Jill Talley as Aunt Denise
- Kari Wahlgren as Henry
- Pamela Adlon as Beau's Mom/Kelly
- Natalie Palamides as Beau
- Susanne Blakeslee as Grandma Susie
- Tress MacNeille as Librarian Tess
- Maria Bamford as Agent Honeydew
- Paget Brewster as Computer
- Tara Strong as Announcer, Lady 1
- Frank Welker as Various creatures, Additional voices
- Dee Bradley Baker as Additional voices
- Cheri Oteri as Mrs. Miller
- Marieve Herington as Missy
- Betsy Sodaro as Trevor, Dexter's double
- Chelsea Kane as Maggie
- Rachael MacFarlane as Dexter's mom ancestor/Helga
- Daran Norris as Hoagie
- Cree Summer as Lily Lily
- Kimberly Brooks as Peg Peg
- Carlos Alazraqui as Dr. Trent
- Ben Diskin as Narrator, Bullet Man
- Frank Welker as Infraggible Krunk
- Tom Kenny as Val Halen
Additional Voices:
- Lily Vonnegut
- Jennifer Hale
- Flula Borg
- Wendi McLendon-Covey
- Fred Tatasciore
- Kate Higgins
- Keone Young
- Lara Jill Miller
- Kate Micucci
- Lacey Chabert
- Erica Luttrell
- Laraine Newman
- Cindy Robinson
- Cree Summer
- Lauren Lapkus
- Lauri Fraser
- Kevin Michael Richardson
- Olivia Olson
- Julia Louis-Dreyfus
- Nicole Sullivan
- Jason Marsden
- Kate Micucci
- Sandy Fox
- Vanessa Marshall
- Laura Bailey
- Eric Bauza
- Jennifer Hale
- Flula Borg
- Wendi McLendon-Covey
- Fred Tatasciore
- Kate Higgins
- Keone Young
- Lara Jill Miller
- Kate Micucci
- Lacey Chabert
- Erica Luttrell
- Laraine Newman
- Cindy Robinson
- Cree Summer
- Lauren Lapkus
- Lauri Fraser
- Kevin Michael Richardson
- Olivia Olson
- Julia Louis-Dreyfus
- Nicole Sullivan
- Jason Marsden
- Kate Micucci
- Sandy Fox
- Vanessa Marshall
- Laura Bailey
- Eric Bauza
- Maurice LaMarche
- Mayim Bialik
- Busy Philipps
- Grey Delisle-Griffin
- Greg Cipes
- Kelsy Abbott
- Renee Dorian
- Kaiji Tang
- Robbie Daymond
- Noel Wells
- Cam Clarke
- Sarah Chalke
- Catherine Reitman
- Steve Blum
- Mick Wingert
- Hiromi Dames
- Billy Bob Thornton
- Yuri Lowenthal