- "It was an inferno in there! An inferno!"
- —Ms. Keane to EMTs
Ms. Natalie Keane is very pretty and is loved by her male students, although the female students don't like her as much, especially Princess Morbucks/ Himeko Shirogane. Miss Keane, like the original, is kind and incredibly patient. Mojo Jojo gets a crush on her and tries very much to win her attention. When the girls' every attempt gets thwarted by Miss Keane not letting them go to the nurse so they don't miss class time, they try telling Miss Keane that they are the PPGZ, but she does not believe them, telling them to go to the nurse because there's something wrong with their heads.
She wears an orange shirt, red vest, brown pants, and has short black hair and light blue eyes. She is patient, beautiful, understanding and very protective of her students, making her a well-liked, motherly figure. She stands 5 feet 1 inches tall (5 feet 3 inches tall in high heels) and weighs 125 lbs.
- "Wait! Girls! You can not beat her up."
- "Because she's my daughter."
- "Girls, before you go recess I want to tell you about my daughter?"
- "Well, she's a dragon and using her fire breath and I’m asking you, have I been a bad mother?"
- "I'm not sure. Maybe I’ve been to hard on her."
- Corner! (Pull back; she sits up, and the girls float slowly that way.)
- Ms. Keane: You know very well what you did. (smiling) The rest of you can go to recess.
- Zip it! (They do so and turn their faces to the wall. Pause.)