Sedusa is the 5th main villain in The Powerpuff Girls. She is a seductive girl with waving evil hair. She always goes in disguise with costumes that are mostly of hot women so she can get what she wants from people. She is Ms. Keane's sister. She is voiced by Jennifer Hale.


Sedusa is a white sexy girl with wavy black hair and a hot skimpy red dress. In later episodes, the sclera in her eyes turn black and she no longer wears lipstick.


Sedusa is evil and always seduces people to get what she wants.

Episode AppearancesEdit

  • Behind the Mask
  • Bank Rubber
  • Seduce Reuse and Recycle
  • Mommy Fearest
  • Bought and Scold (Non-Speaking Cameo)
  • Crimery Gold
  • Daylight Savings (Non-Speaking Cameo)
  • Equal Fights (Mentioned)
  • Something's a Mrs.
  • The Boys are Back in Town
  • Pop Startled
  • Divide and Conquer (Pictured)
  • Shotgun Wedding (Pictured)
  • Cop Out
  • See Me, Feel Me, Gnomey
  • Aspirations
  • The Vase of Evil
  • The League of Lovely Ladies
  • The Head of Sedusa
  • Roughing it Up (Non-Speaking Cameo)
  • The Powerpuff Girls Rule!!!

Powerpuff Girl ZEdit

In Powerpuff Girl Z, Sedusa is really a girl named Annie who constantly changes into an evil Sedusa. See Sedusa/Annie.


  • She is a parody on Medusa because of her name and her wavy hair. They even made a reference to it in the episode "The Head of Sedusa" where Sedusa got the power to turn people into stone and The Powerpuff Girls had to slice off her head. They also made another reference to it in the episode "Aspirations" where Sedusa put on a greek crown and it turned her hair into snakes.
  • The Seduce part if her name is a pun on the fact that she seduces people.
  • In the episode "Something's a Mrs." Sedusa's hair got cut off and it was supposed to stay that way until the episode "Aspirations" but there were episodes in between those two where Sedusa clearly had a full head of hair. The episodes are these of the following:
    • The Boys are Back in Town
    • Pop Startled
    • Cop Out
    • See Me, Feel Me, Gnomey

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