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Spider-Man/Powerpuff Girls: The Rise of Demogoblin is a 1-hour special of the stop motion series Spider-Man: Power and Responsibility, as well as a direct sequel to the previous special Spider-Man/Powerpuff Girls: The Eight-Armed Monkey.

The special follows Miles Morales, the current Spider-Man, as he tries to help the reality-displaced Powerpuff Girls find their way back to their home dimension. Meanwhile, the demonic villain HIM encounters Harry Osborn, the second Green Goblin, and the two join forces in order to destroy the heroes of their respective universes, eventually merging into Power and Responsibility's Demogoblin.

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